The solution space of metabolic networks: producibility, robustness and fluctuations

Flux analysis is a class of constraint-based approaches to the study of biochemical reaction networks: they are based on determining the reaction flux configurations compatible with given stoichiometric and thermodynamic constraints. One of its main areas of application is the study of cellular metabolic networks. We briefly and selectively review the main approaches to this problem and then, building on recent work, we provide a characterization of the productive capabilities of the metabolic network of the bacterium E.coli in a specified growth medium in terms of the producible biochemical species. While a robust and physiologically meaningful production profile clearly emerges (including biomass components, biomass products, waste etc.), the underlying constraints still allow for significant fluctuations even in key metabolites like ATP and, as a consequence, apparently lay the ground for very different growth scenarios.Comment: 10 pages, prepared for the Proceedings of the International Workshop on Statistical-Mechanical Informatics, March 7-10, 2010, Kyoto, Japa

Neural Mechanisms Underlying Paradoxical Performance for Monetary Incentives Are Driven by Loss Aversion

Employers often make payment contingent on performance in order to motivate workers. We used fMRI with a novel incentivized skill task to examine the neural processes underlying behavioral responses to performance-based pay. We found that individuals’ performance increased with increasing incentives; however, very high incentive levels led to the paradoxical consequence of worse performance. Between initial incentive presentation and task execution, striatal activity rapidly switched between activation and deactivation in response to increasing incentives. Critically, decrements in performance and striatal deactivations were directly predicted by an independent measure of behavioral loss aversion. These results suggest that incentives associated with successful task performance are initially encoded as a potential gain; however, when actually performing a task, individuals encode the potential loss that would arise from failure

HT Camelopardalis: The simplest intermediate polar spin pulse

The intermediate polar HT Cam is unusual in that it shows no evidence for dense absorption in its spectrum. We analyse an XMM-Newton observation of this star, which confirms the absence of absorption and shows that the X-ray spin-pulse is energy independent. The modulation arises solely from occultation effects and can be reproduced by a simple geometrical model in which the lower accretion footprint is fainter than the upper one. We suggest that the lack of opacity in the accretion columns of HT Cam, and also of EX Hya and V1025 Cen, results from a low accretion rate owing to their being below the cataclysmic variable period gap.Comment: 5 pages, 6 figures, accepted for publication in MNRA

Upper Triassic basinal carbonates between the Molise and Sannio Nappes near Frosolone (Duronia, Molise): geological implications.

E’ stata riconosciuta nell’area di Duronia (Molise) l’esistenza di dolomie e calcari dolomitici con selce del Trias superiore riferibili alla Formazione dei “Calcari con Selce” delle Unità Lagonegresi. Questi carbonati bacinali, presenti nella parte basale della Falda Sannitica in prossimità del contatto con le Falde Molisane (Unità di Frosolone), sono stati interpretati in passato come olistoliti all’interno delle Argille Varicolori, come depositi della successione sannitica o come depositi della successione sicilide e ad essi sono state attribuite età che vanno dal Cretaceo superiore al Miocene medio. L’esistenza di depositi bacinali triassici nella regione molisano-sannitica ha come implicazione paleogeografica la continuazione verso nord di un ramo del Bacino Lagonegrese e come implicazione tettonica un forte raccorciamento tra i massicci carbonatici riferibili alla Piattaforma Appenninica e quelli riferibili alla Piattaforma Simbruini-Matese

Statistical mechanics of the mixed majority-minority game with random external information

We study the asymptotic macroscopic properties of the mixed majority-minority game, modeling a population in which two types of heterogeneous adaptive agents, namely ``fundamentalists'' driven by differentiation and ``trend-followers'' driven by imitation, interact. The presence of a fraction f of trend-followers is shown to induce (a) a significant loss of informational efficiency with respect to a pure minority game (in particular, an efficient, unpredictable phase exists only for f<1/2), and (b) a catastrophic increase of global fluctuations for f>1/2. We solve the model by means of an approximate static (replica) theory and by a direct dynamical (generating functional) technique. The two approaches coincide and match numerical results convincingly.Comment: 19 pages, 3 figure

GPS time series at Campi Flegrei caldera (2000-2013)

The Campi Flegrei caldera is an active volcanic system associated to a high volcanic risk, and represents a well known and peculiar example of ground deformations (bradyseism), characterized by intense uplift periods, followed by subsidence phases with some episodic superimposed mini-uplifts. Ground deformation is an important volcanic precursor, and, its continuous monitoring, is one of the main tool for short time forecast of eruptive activity. This paper provides an overview of the continuous GPS monitoring of the Campi Flegrei caldera from January 2000 to July 2013, including network operations, data recording and processing, and data products. In this period the GPS time series allowed continuous and accurate tracking of ground deformation of the area. Seven main uplift episodes were detected, and during each uplift period, the recurrent horizontal displacement pattern, radial from the “caldera center”, suggests no significant change in deformation source geometry and location occurs. The complete archive of GPS time series at Campi Flegrei area is reported in the Supplementary materials. These data can be usefull for the scientific community in improving the research on Campi Flegrei caldera dynamic and hazard assessment

Constraining the redshift evolution of the Cosmic Microwave Background black-body temperature with PLANCK data

We constrain the deviation of adiabatic evolution of the Universe using the data on the Cosmic Microwave Background (CMB) temperature anisotropies measured by the {\it Planck} satellite and a sample of 481 X-ray selected clusters with spectroscopically measured redshifts. To avoid antenna beam effects, we bring all the maps to the same resolution. We use a CMB template to subtract the cosmological signal while preserving the Thermal Sunyaev-Zeldovich (TSZ) anisotropies; next, we remove galactic foreground emissions around each cluster and we mask out all known point sources. If the CMB black-body temperature scales with redshift as $T(z)=T_0(1+z)^{1-\alpha}$, we constrain deviations of adiabatic evolution to be $\alpha=-0.007\pm 0.013$, consistent with the temperature-redshift relation of the standard cosmological model. This result could suffer from a potential bias $\delta\alpha$ associated with the CMB template, that we quantify it to be $|\delta\alpha|\le 0.02$ and with the same sign than the measured value of $\alpha$, but is free from those biases associated with using TSZ selected clusters; it represents the best constraint to date of the temperature-redshift relation of the Big-Bang model using only CMB data, confirming previous results.Comment: ApJ, in press. Manuscript matches the accepted version: 10 pages, 7 figures, 3 table

Histamine plasma levels and elimination diet in chronic idiopathic urticaria

Abstract: Objective: The aim of this study was to evaluate the effects of an oligoantigenic and histamine-free diet on patients affected with chronic idiopathic urticaria (CIU). Design: Ten patients with chronic idiopathic urticaria were prescribed an oligoantigenic and histamine-free diet for 21 days, followed by serial and controlled reintroduction of foods during a further 70 days. Modification in clinical illness as well as histamine plasma levels, post-heparin plasma diamine oxidase (DAO) and intestinal permeability were evaluated. Results: The oligoantigenic and histamine-free diet induced a significant improvement of symptoms (P < 0.05). Moreover, CIU patients on free diet showed higher histamine plasma levels (P < 0.05 vs post-diet and vs controls) that fell to control levels during the oligoantigenic and histamine-free diet. Post-heparin plasma diamine oxidase values were slightly reduced and were unchanged during the diet as well as intestinal permeability, which was always normal in all patients. Conclusions: These data suggest that histamine plays a major role in chronic idiopathic urticaria. The finding of normal intestinal permeability suggests that a morphological damage of intestinal mucosa should be excluded in these patients. However, the presence of low levels of post-heparin plasma diamine oxidase may indicate a subclinical impairment of small bowel enterocyte function that could induce a higher sensitivity to histamine-rich or histamine-producing food